Jennifer Aniston is known for cherishing her friendships, particularly with her former Friends co-stars Courteney Cox and Lisa Kudrow. Aniston expressed her love and admiration for Cox during her Hollywood Walk of Fame ceremony in February 2023, which Kudrow also attended. Aniston confessed to being nervous when meeting Cox for the first time because she was a huge fan. However, she quickly realized that Cox is a warm, inclusive, and loving person who is genuinely interested in others.

Cox also instilled an important lesson in Aniston and her Friends co-stars - the importance of supporting and loving one another instead of competing. Aniston credits Cox's wise words with setting her on the path of nurturing creative relationships throughout her career. Aniston describes Cox as a really good human and an extraordinary friend. In addition to Cox and Kudrow, Aniston's inner circle also includes other famous friends. Jimmy Kimmel, who is a close friend, officiated Aniston's wedding to Justin Theroux in 2015. Another friend, Adam Sandler, has been a part of Aniston's life since they met at Jerry's Famous Deli in the 90s. They have even worked together on films like Just Go With It and Murder Mystery. Aniston and Kudrow have been friends since their days on Friends and celebrate each other's birthdays with heartfelt messages on social media. Reese Witherspoon, who made a guest appearance on Friends, has also formed a close bond with Aniston. The two now star together in The Morning Show. Sandra Bullock, another longtime friend, has a similar history with Aniston and even jokes about both of them dating actor Tate Donovan. Other friends in Aniston's inner circle include Chelsea Handler, Jason Bateman, hairstylist Chris McMillan, and Andrea Bendewald, who has been friends with Aniston since they were 14.

Aniston and Bendewald even have matching tattoos to symbolize their lasting friendship. Overall, Aniston treasures her friendships and considers her close friends to be like family. These relationships have played a significant role in shaping her personal and professional life.