The San Francisco 49ers reached out to Ben Roethlisberger's agent during the 2022 season to gauge his interest in joining the team due to their quarterback injuries. Roethlisberger admitted to being intrigued by the offer but ultimately couldn't see himself in any other jersey than the Pittsburgh Steelers'. He discussed the situation on his podcast, stating that the 49ers were simply gauging his interest.
Roethlisberger retired at the end of the 2021 season after 18 seasons with the Steelers. In the same podcast episode, he also shared his thoughts on Baltimore Ravens quarterback Lamar Jackson.