In the pilot, after Dean shows up to fetch Sam because their father, John, has been missing, he and Sam have a disagreement, establishing their two opposing views on the hunter lifestyle. Sam argues against joining Dean and complains about John's obsession with finding the demon who killed their mother, Mary.
Dean says, "," to which Sam replies, "." Dean responds, "." This admission spurs Sam to concede and join the search for John.
In Dean's death scene, Sam, while in tears, says, "," setting off the same dialogue from the pilot but with the brothers saying each other's original lines. To add even more to this parallel, Dean references the scene prior to where the pilot's dialogue comes from — when he shows up at Stanford.
Dean confesses he was worried Sam would not have gone with him that day because it was "," indicating he couldn't imagine a world without Sam. Now, he reassures Sam, who clearly doesn't feel ready to say goodbye, by saying, "
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