Rose - Mila Kunis

Rose is the woman who lives in the apartment below Charlie's beach house and is completely obsessed with the musician. She is so infatuated with him that she is willing to overlook how promiscuous he is and how disrespectful of women he is.

The only other actress working in TV that can put forward that amount of erraticness is Mila Kunis.

Her work on That 70's Show as the wealthy and controlling Jackie Burkhart is what Rose would be like if she actually found herself in a relationship with Charlie.

Walden Schmidt - John Krasinski

Walden Schmidt, the tech guru who replaced Charlie Sheen, might not be one of the fans' favorite characters, as his entrance was one of the worst season premiers of the show, but Ashton Kutcher did the best he could in the wake of Sheen's absence.

He's the younger, more attractive, more sarcastic, and much smarter version of Charlie, and the perfect actor to take up the mantle is John Krasinski. The former The Office actor is already naturally sarcastic, not to mention charming and supremely handsome.

Herb Melnick - Bob Odenkirk

Bob Odenkirk has been on the TV sitcom circuit for decades now, as he had a hilarious feature in Seinfeld, and then in Curb Your Enthusiasm, and he of course had his own show with David Cross, Mr. Show.

Odenkirk would be the perfect comedian to replace, Ryan Stiles, also a comedic heavyweight from the 1990s. As the character of Herb is socially awkward and finds himself in a semi-abusive relationship with Judith, he is one of the best recurring characters, and Odenkirk has always been a great supporting character.

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