Mary Campbell was accepted at Kansas State University before season finale, but she decided to go on a trip to discover her identity without the influence of all the alternative versions she saw in the portal with Dean and the Impala. Mary could well decide to go and study at university if she and John settle down somewhere.
Their future is wide open thanks to the Winchester boys from primary timeline.
On their travels, they have the freedom to choose their own destiny as Dean encouraged them to do. John was gifted Dean's own hunting journal and Mary the colt capable of taking down the yellow-eyed demon but did they end up needing to use these gifts? They could have used both to defend themselves and stay safe, or they could have continued their hunting career.
In Supernatural, it's less John and Mary finding the yellow-eyed demon and more the other way around.
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