Topher Grace reflects on his role as Venom in Spider-Man 3 and his departure from That '70s Show. He expresses surprise at being offered the role and praises the film despite mixed reactions. Grace also discusses the success of his co-stars, highlighting their accomplishments in other projects. He maintains a positive outlook on his own career and the experiences he had both on and off the show. Lastly, fans are excited to see him reprise his role in That '90s Show.