The article discusses the Instagram popularity of the cast members of the sitcom Two And A Half Men. While the main cast members such as Jon Cryer and Charlie Sheen have a significant following, other notable names like Angus T. Jones and Marin Hinkle have fewer followers. It is noted that Instagram popularity does not necessarily reflect overall popularity. The article also mentions the Instagram presence and activities of other cast members, including Melanie Lynskey, Graham Patrick Martin, Jennifer Taylor, Holland Taylor, April Bowlby, Amber Tamblyn, Judy Greer, Charlie Sheen, and Ashton Kutcher. The top two actors with the most Instagram followers are Charlie Sheen and Ashton Kutcher.